Calcium Channel Blockers (Milestones in Drug Therapy)

The main effect of calcium channel blockers is the blockade of calcium entry into cells through voltage operated calcium channels. This volume gives a comprehensive overview of the different classes of CCBs and their various effects. It covers historical development, pharmacology, clinical aspects, and perspectives. All chapters are written by Prof. T. Godfraind, a world leading expert in the field.

Publisher: Birkhauser Verlag AG

Published: Switzerland, 26 March 2004

Format: Hardback, 262 pages

Age Range: 0+

Other Information: XIV, 262 p.

Dimensions: 23.4 x 15.6 x 1.8 centimeters (0.78 kg)

Writer: Godfraind Theophile, Eric Ertel

Table of ContentsHistorical perspective: from early steps on calcium research to the identification of calcium antagonist prototypes and of the signaling functions of Ca2+.- Calcium channel blockers and calcium channels.- The action of calcium antagonists on Ca2+ movements in isolated vessels.- The tissue selectivity of calcium antagonists.- Acute haemodynamic effects of calcium channel blockers.- Calcium channels and regulation of vascular tone in hypertension.- Long-term effects of calcium antagonists.- Blood pressure-independent effects of calcium antagonists.- From early clinical studies to randomized controlled clinical trials.- Beyond the cardiovascular system.